Mice have been found to be the most closely related laboratory
animal species to humans with the knockout technique being
easily applied. Mice are used in experiments largely for this
reason and to help answer questions related to human physiology.
Rats used for gene knockout is much harder and has only been
possible since 2003.
In 1989 the first recorded knockout mouse was created by Mario
R. Capecchi, Martin Evans and Oliver Smithies. They were awarded
the Nobel Prize for Medicine in 2007.
Aspects of the technology for generating knockout mice, and the
mice themselves have been patented in many countries by private
By Knocking out the activity of a gene provides information
about what that gene would normally do. With Humans sharing many
genes with mice, observing the characteristics of mice that have
had genes knocked out will give researchers information that can
be used to better understand how a similar gene in humans may
cause or contribute to disease.
Research with the use of knockout mice has been very useful in
the study and modelling of the likes of different kinds of
cancer, heart disease, diabetes, obesity, arthritis, anxiety,
substance abuse, Parkinsonís disease and aging. Knockout mice
also provide a biological and scientific background in which
drugs and other therapies can be developed and tested.
A mouse can be annoying where mice can be a bigger problem!
Getting rid of mice can be done in many ways such as the use of
traps that kill or catch and poisons. Controlling mice in and
around your home must be taken seriously as they can introduce
illnesses to your family as well as transfer fleas to pets.